“Double Dose:” One Treatment Helped Pain and Promoted Healing

Researchers at Penn State (Hershey) were investigating bone fracture healing when they made a serendipitous discovery about the potential restorative power of Cannabidiol (CBD) and Cannabigerol (CBG). The original study, published in Journal of Bone and Mineral Research, sought to identify pain management medicines for bone fractures, since standard care such as nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the inflammatory process needed for healing, while opioid use could lead to addiction.

Researchers treated tibial fractures in mice with two non-psychotropic cannabinoids, CBD and CBG. They found that both CBD and CBG normalized pain sensitivity, and their analgesic effects were comparable to NSAIDs. The bonus discovery—CBD and CBG promoted bone healing in the mice, indicating that cannabinoids could possibly help bone fracture patients heal, as well as manage pain.

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