research/study

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New insights into pain pathways suggest that existing approaches to assessing the efficacy of novel compounds for pain may be flawed, leading to the discounting of possibly effective candidates. A research team led by investigators from Harvard Medical School reports that it has identified the nerve...

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A research team from University of California, San Diego and the Virginia Tech School of Neuroscience will be working to test the efficacy of a new compound discovered by the National Institutes of Health as a nonopioid treatment alternative for chronic pain. The compound, ML351, inhibits the...

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Patients who suffer chronic colitis and inflammatory bowel disease are at risk for development of colorectal dysplasia and colorectal cancer (CRC). Colorectal neoplasia (CRN), an abnormal cell mass that can be either benign or malignant, is often monitored as an early sign of cancer. A recent study...

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Findings from a new analysis conducted in Finland highlight a range of conditions that can increase the risk of complications from total hip replacement surgery and surgery for hip fracture. Demographically, this is an escalating concern, as an aging population is anticipated to require more hip...

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Working with rodent models, engineers from University of Wisconsin-Madison have developed a new, low-cost dressing that cuts wound healing time from the normal 2 weeks to just 3 days. The device makes use of electricity, long known to accelerate skin healing, but in a more compact and efficient way...

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A study published last month in the journal Arthritis & Rheumatology concludes that pain sensitization is a significant risk factor for the development of persistent knee pain from osteoarthritis (OA). OA impacts some 302 million adults worldwide, frequently occurring in the knee joint and often...

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Immune checkpoint inhibitors (ICIs) are successfully used against several types of cancer, but a common side effect of this immunotherapy is ICI-associated colitis, which occurs in up to 40% of patients. If sufficiently severe, treatment guidelines direct that ICI therapy be discontinued until the...

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Researchers from Ohio State University report that eliminating one type of immune cell in the brain is effective in preventing inflammation following traumatic brain injury. The finding may represent a significant advance in the treatment of severe brain injury, for which there are no approved...

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The Department of Defense has awarded Kevin Baker, PhD, Beaumont Health director of orthopedic research, a $1.5 million grant to investigate new approaches to forestall the onset of post-traumatic osteoarthritis (PTOA), a condition that can occur following anterior cruciate ligament knee injury. The...

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Does more walking mean increased risk for degeneration of the knee joint in those with osteoarthritis (OA), leading to more total knee arthroplasty (TKA)? Research to date has returned inconsistent results, and a team from University of Delaware reported their findings last week at the 2018 ACR/ARHP...

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