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Migraine is among the most disabling disorders in the world, and much of the treatment armamentarium to date comes with significant unwanted effects. But new advances in our understanding of neurotransmitters and sensory processing may have led us to the dawn of a new and better era of migraine...
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Botulinum toxin, usually referenced by the brand name Botox®, received FDA approval as a treatment for chronic migraine in 2010. An updated review and meta-analysis of pooled clinical trial data now provides further confirmation of its efficacy, concluding that Botox is superior to placebo for the...
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Researchers from the Center for Applied Genomics at Children’s Hospital of Philadelphia report the discovery of gene variants that are associated with elevated risk for migraine in African-American children. The authors state that the findings may inform the development of targeted treatments for...
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A data review conducted by researchers from the Instituto de Biología Molecular y Celular, Universitas Miguel Hernández, Elche, Spain concludes that sex hormones may contribute to modulation of transient receptor potential (TRP) channels’ expression and activity, thereby impacting sensitization in...
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Conclusions from a recent cross-sectional study investigating the association between diabetes mellitus and migraine found no significant differences in the prevalence of migraine between age- and sex-matched diabetic and nondiabetic subjects, after adjusting for possible confounding variables. The...
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Approximately 1 billion people in the world are affected with migraine and the thought is that about 40% of them that are candidates for some type of preventative therapy. A sizable proportion of that 40% doesn’t actually receive the kind of preventative therapy that they need, and so that equates...
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Headache, by itself, is just a symptom. It’s like saying someone has arm pain; there are many causes of arm pain. There are over 300 different causes of headache; some of them are threatening, secondary headaches; some of them are not threatening but problematic--those are primary headaches. Once...
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Researchers at Mayo Clinic, in collaboration with other major headache centers in the US, report favorable results from a study of single-pulse transcranial magnetic stimulation as an approach to prevention of migraine headache. In the study, entitled eNeura SpringTMS Post-Market Observational U.S....
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Both the central nervous system and the peripheral nervous system are heavily involved in starting and continuing a migraine attack, and are involved before the migraine even starts. If you divide a migraine into premonitory phases–the aura, the migraine phase and then the postdrome, with modern...
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Dr. Ward discusses points of differential diagnosis and strategies for treatment selection that can promote better outcomes for migraine sufferers. The Migraine Treatment Optimization Questionnaire is a tool that can help the clinician address unmet needs for their patients.