| Article

A letter published in the journal of Signal Transduction and Targeted Therapy brings to light a potential new tool to combat chronic pain. Conolidine, used in traditional Chinese medicine, is a natural analgesic alkaloid that targets the atypical chemokine receptor ACKR3. Researchers say it offers...

| Article

Children are not small adults. If drugs are first tested on adults, and they usually are, how do we know how much is too much for children? An article in Statistics in Medicine brings up these important questions for discussion. In it, researchers “propose a model based on a non‐parametric...

| Article

In an article in the PNAS journal, researchers report the power of 3 antibiotics against chronic pain, possibly reducing the need for opioids. The study abstract reports that “demeclocycline, chlortetracycline, and minocycline can be repurposed for treatment of neuropathic pain and potentially for...

| Podcast

It is becoming increasingly common to hear a new analgesic drug molecule described as a “biased ligand,” being “peripherally restricted,” or as having been “engineered.” What do these terms mean? How are such drugs designed or discovered, and how do you even know that you have one when you have one...

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From the FDA:

CURE ID is an internet-based repository that lets the clinical community report novel uses of existing drugs for difficult-to-treat infectious diseases through a website, a smartphone or other mobile device. The platform enables the crowdsourcing of medical information from health...

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Newswise—Psychedelic drugs could be effective in treating psychiatric disorders such as depression and post-traumatic stress disorder, but medical use of these drugs is limited by the hallucinations they cause.

“What if we could redesign drugs to keep their benefits while eliminating their...

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Scientists from Hong Kong Baptist University (HKBU) have developed a novel technique that can produce pure therapeutic drugs without the associated side effects.

The approach, which uses a nanostructure fabrication device, can manipulate the chirality of drug molecules by controlling the...

| Article

A pre-planned analysis of the CARD trial (NCT02485691) demonstrated better patient-reported outcomes (PROs) with cabazitaxel (Jevtana) compared with either abiraterone (Zytiga) or enzalutamide (Xtandi) in men with metastatic castration-resistant prostate cancer (mCRPC) who were previously treated...

| Article

Newswise — McMaster University researchers have identified an antibacterial compound made by cannabis plants that may serve as a lead for new drug development.

An interdisciplinary team of McMaster researchers found that the chemical compound, or cannabinoid, called cannabigerol (CBG) is not only...

| Article

Newswise — An international research team has developed a new strategy that can predict the potential clinical implications of new therapeutic compounds based on simple cellular responses. This discovery was partly led by scientists affiliated with Université de Montréal (UdeM), and represents a...

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