| Article

From the European Journal of Medicinal Chemistry


• We describe a novel class of diethylaminocarbonyl-2-benzenesulfamide analogs to acetaminophen/paracetamol.

• Compounds, 3b and 3r, lack the hepatotoxicity present in acetaminophen/paracetamol.

• 3b and 3r maintain analgesia...

| Article

Newswise — About 29 million Americans use over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) to treat pain. Every year in the United States, NSAID use is attributed to approximately 100,000 hospitalizations and 17,000 deaths. In addition, the U.S. Food and Drug Administration recently...

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Acetaminophen has been available in the U.S. without a prescription since 1955. Concerns about its potential link to cancer come from its relationship to another drug: phenacetin. That drug, once a common treatment for headaches and other ailments, was banned by the FDA in 1983 because it caused...

| Article

One consequence of the public health crisis of opioid abuse has been an increased interest in the practice of multimodal analgesia for postsurgical pain management. Jacques YaDeau, MD, an anesthesiologist at Hospital for Special Surgery (HSS) in New York, remarked, “How to optimize multimodal...

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