Topical and transdermal analgesics are frequently used to provide an opioid-sparing effect, or serve to facilitate analgesic delivery by a non-oral route of administration. However, most practitioners are unaware of the role in therapy for these analgesics. Participants in this session will learn about the efficacy and toxicity of topical analgesics including commercially available products such as capsaicin, salicylates, counterirritants, nonsteroidal anti-inflammatory drugs, and lidocaine and compounded topical opioids for wound care pain. The appropriate use of transdermal buprenorphine and fentanyl will also be discussed. By using a case-based active-learning approach, participants will learn which patient scenarios are amenable to topical analgesic therapy.