This lecture reviews the evaluation and treatment of persistent chronic neuropathic and nonneuropathic pain. Certain chronic pain profiles may not respond well to traditional mainstream medical and/or surgical management. Spinal cord stimulation therapy is most effective in treatment of neuropathic pain states such as monoradicular pain. Other conditions such as complex regional pain syndrome 1 and 2 may also benefit from spinal cord stimulation. When considering spinal cord stimulation therapy, patient selection is critical for a successful outcome. Therefore, the benefits and limitations as well as patient expectations should be completely reviewed with each patient prior to entering into a trial of spinal cord stimulation.