The high prevalence of chronic pain has become an immense public health problem. Diet is one of the possible analgesic modalities currently explored within the growing field of complementary and alternative medicine. Unfortunately, while proven to play a crucial role in the prevention of multifactorial illnesses such as cancer and ischemic heart disease, only scarce scientific data on the analgesic properties of diet exist. Nevertheless, preclinical and clinical studies have associated certain dietary factors with analgesia, indicating that diet could potentially play a significant role in relieving both acute and chronic pain. This course reviews basic and clinical evidence supporting dietary-induced analgesia and suggests possible future research avenues to further expand our knowledge of this neglected area.