| One-Minute Clinician

Abuse Deterrent Formulation Types and Goals

Abuse deterrent formulations: different manners of preventing someone from transgressing to the inhalation or snorting of medications, or intravenous use.

  • Aversion: if someone attempts to abuse the product it would not feel good. For instance, if the product is crushed and snorted, the nose is going to feel very bad
  • Opioid antagonists products: if someone utilizes the medication as intended, fine, but if it’s abused, misused, or crushed, a second medication will be activated and block the medication
  • Coatings: where the medicines aren’t activated, are not absorbed in the stomach or GI tract until a specific point. pH comes into play: how acidic is the environment? If the medication is coated, it won’t be absorbed in the stomach

The big idea:

  • Smart goals: the intention is not to be The Panacea: nothing is going to take care of everything
  • Even with future technologies—multi-pill abuse resistance, other formulations of ADFs, etc—the goal is to prevent the transgression to injection, snorting, abusing. That is one tool in the overall toolbox for risk reduction for both the patient and the practitioner