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In an article in the PNAS journal, researchers report the power of 3 antibiotics against chronic pain, possibly reducing the need for opioids. The study abstract reports that “demeclocycline, chlortetracycline, and minocycline can be repurposed for treatment of neuropathic pain and potentially for...
| Podcast
It is becoming increasingly common to hear a new analgesic drug molecule described as a “biased ligand,” being “peripherally restricted,” or as having been “engineered.” What do these terms mean? How are such drugs designed or discovered, and how do you even know that you have one when you have one...
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From the FDA:
CURE ID is an internet-based repository that lets the clinical community report novel uses of existing drugs for difficult-to-treat infectious diseases through a website, a smartphone or other mobile device. The platform enables the crowdsourcing of medical information from health...
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Newswise—Psychedelic drugs could be effective in treating psychiatric disorders such as depression and post-traumatic stress disorder, but medical use of these drugs is limited by the hallucinations they cause.
“What if we could redesign drugs to keep their benefits while eliminating their...
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Scientists from Hong Kong Baptist University (HKBU) have developed a novel technique that can produce pure therapeutic drugs without the associated side effects.
The approach, which uses a nanostructure fabrication device, can manipulate the chirality of drug molecules by controlling the...
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A pre-planned analysis of the CARD trial (NCT02485691) demonstrated better patient-reported outcomes (PROs) with cabazitaxel (Jevtana) compared with either abiraterone (Zytiga) or enzalutamide (Xtandi) in men with metastatic castration-resistant prostate cancer (mCRPC) who were previously treated...
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Newswise — McMaster University researchers have identified an antibacterial compound made by cannabis plants that may serve as a lead for new drug development.
An interdisciplinary team of McMaster researchers found that the chemical compound, or cannabinoid, called cannabigerol (CBG) is not only...
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Newswise — An international research team has developed a new strategy that can predict the potential clinical implications of new therapeutic compounds based on simple cellular responses. This discovery was partly led by scientists affiliated with Université de Montréal (UdeM), and represents a...
| Podcast
Surveys of healthcare providers indicate that one of the most distressing features of clinical practice is that of patient nonadherence. Its incidence in pain medicine is concerning: over 50% of patients with chronic noncancer pain are nonadherent with their prescribed exercise treatment and up to...
| Podcast
In professional practice, numerous medications are disguised as “muscle relaxants”; however, just how many actually are true relaxants of peripheral muscle? In this discussion on the overall classes of muscle relaxants, we will endeavor to evaluate these medications based on respective mechanisms of...