Study Spotlights Role of Enhanced Immune Response in Central Sensitization

A new study appearing online in advance of publication in the journal Pain reports that an enhanced innate immune response may be an indicator of the onset or prolongation of chronic, multisite musculoskeletal pain. This immune response involves proinflammatory cytokines that may induce central sensitization and contribute to pain hypersensitivity.

The study researchers found that 307 patients with chronic, multisite musculoskeletal pain had significantly higher levels of a number of lipopolysaccharide (LPS)-stimulated proinflammatory cytokines than 400 individuals without such pain after taking into account lifestyle and disease variables. They conclude that the findings suggest that the innate immune response could be examined as a potential biomarker for the onset and perpetuation of chronic pain. Read a news report, with link to the study abstract, here.


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