IBS Symptom Improvements Shown With Altered Microbiome Composition

Findings from a recent study appearing this month in Alimentary Pharmacology & Therapeutics suggest dietary modifications that may improve symptoms and pain for children with irritable bowel syndrome (IBS). The research took the form of a randomized, double-blind crossover trial of children aged 7 to 17 years with Rome III-defined IBS. The purpose was to evaluate the efficacy of low fermentable oligosaccharides, disaccharides, monosaccharides, and polylols (FODMAP) diet in pediatric IBS, and to determine if gut microbial composition or metabolic capacity are associated with response to the diet.

The study found that patients who received the low FODMAP diet vs a typical American diet experienced fewer abdominal pain events. Additionally, of the patients who exhibited improvement, baseline gut microbial compositions were enriched with taxa known to have greater saccharolytic metabolic capacity. The study authors state that future research may shed light on whether evaluation of the gut microbiome can assist in devising of personalized dietary intervention therapy to treat pediatric IBS.

A news story about the findings, with link to the journal abstract, may be read here.



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