A Possible Route to More Effective Therapies for Arthritis, Shingles, Back Pain

A research paper published this week in the journal Neuron reports the discovery of a new target for treating chronic pain: the enzyme PIP5K1C, which was demonstrated to control the activity of pain sensing neurons. The researchers also report the discovery of a compound that could dampen the activity of this enzyme.

By reducing the level of the targeted enzyme, the UNC School of Medicine researchers showed that the levels of a crucial lipid called PIP2 in pain-sensing neurons is also lessened, thus decreasing pain. Discovery of the enzyme-blocking compound, UNC3230 was effected by engaging additional research scientists from the Eshelman School of Pharmacy at UNC. This compound could provide insight into the development of new, and more effective pain relieving medications. Read a news story about the findings here.

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