Why and how do people tamper with medications? Does tampering increase the risk of overdosing? Dr. Beatrice Setnik discusses abuse potential and evolving regulatory requirements for clinical methodology. The methods to deter abuse have evolved over time and include various approaches including mitigating overdose when multiple tablets are combined to the addition of various unpleasant excipients such as gelling, strong dyes, or unpleasant smells or tastes. But tamperers manage to find ways around these approaches. What real world solutions will help clinicians and their patients?
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