A large percentage of geriatric patients have depression along with comorbid pain. Improvements in both were shown in a multicenter, placebo-controlled 24-week study of almost 300 patients 65 or older. Although the randomized trial didn’t meet its primary end point, results did show meaningful reduction in pain severity and interference for participants in the duloxetine group compared with the placebo group.
Participants were elderly patients with major depressive disorder based on Montgomery-Asberg Depression Rating Scale and Mini-Mental Examination scores, as well as mild to moderate pain according to a Brief Pain Inventory and Pain Numeric Rating Scale scores. Although most weeks of the study did show statistically significant changes in the HAMD-17 Maier subscale, at week 12, the primary end point, it fell short.
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