BIN1 Level Can Approximate Heart Health and Patient Outcomes

In a new study published in Nature Medicine, researchers at the Cedars-Sinai Heart Institute suggest that therapeutic options may be offered through the study of the BIN1 heart-specific form of protein. Findings from studies of lab mice show “how heart cells are organized” and provide “insight into the way heart cells change when hearts start to fail,” said Robin Shaw, MD, PhD, of the Heart Institute. A decrease in BIN1 predicts arrhythmia, because that decrease signals a decrease in protective microfolds.

The hope is that eventually a biochemical assessment of a BIN1 blood test might measure what’s going on in the heart. Currently, ultrasound images are used to gauge heart health, but cardiologists feel it is a poor outcome indicator. BIN1 is found in other parts of the body as well as the heart. The lead author of this study, TingTing Hong, MD, PhD, will devote her lab to the investigation of BIN1.

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