Applications of laboratory pain methodologies in research with children and adolescents: Emerging research trends

Historically, laboratory pain research with children and adolescents has largely been conducted with healthy samples using the cold pressor task (CPT). Additional laboratory methodologies, commonly referred to as quantitative sensory testing (QST), include a variety of psychophysical tests assessing sensory perception (eg, pressure and heat tolerance) and sensory abnormalities. There is significant variation in QST protocols in terms of methodology (eg, number and type of measurement modalities) and data gleaned (eg, pain threshold vs central sensitization).

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