New Biological Mechanisms Linked to Triggers of Rheumatoid Arthritis

A study published online this week in the journal Science Translational Medicine, lends new credence to the hypothesis that immune pathways activated in response to pathogens play a role in initiating immune responses in rheumatoid arthritis. Researchers found that two pore-forming pathways in cell membranes, known as perforin and membrane attack complex (MAC), are active contributors in generating the targets to the immune response, or auto-antigens, thought to initiate and maintain inflammation in rheumatoid arthritis. Inhibiting these pathways may open up new avenues for treatment of the autoimmune condition. Read more about the study here.


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