The Perfect "Solution"

Author: Annas Aljassem

Topically applied opioids have provided effective analgesia without adverse effects in adult patients with painful inflammatory conditions. The presumed mechanism of action is by interaction with opioid receptors that are sited on sensory nerve terminals, which may be upregulated in inflammation. A topical solution may result in rapid reduction in patient reported pain scores without reported adverse effects or tolerance. This treatment modality has been a successful addition to our practice. We run the Functional Pain & Rehabilitation Service that treats pain for patients with complex pain syndromes with focus on functional restoration at a 1,000+ bed Level 1 trauma-accredited academic teaching hospital and outpatient services in Royal Oak, Michigan.

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