Analgesic of the Future: A New Opioid Molecule With Slow Entry Into the CNS

Sponsored by Nektar Therapeutics

This activity is not certified for credit.

Wednesday, September 6

Start Time

End Time

Castellana Ballroom
Level 3

Program Description
Opioids are considered the most effective therapeutic option for pain, but come with unwanted CNS side effects including dizziness, sleepiness, respiratory depression and the potential for abuse and addiction. Opioid abuse remains a major public health problem, despite heightened awareness among healthcare professionals, patients, the public and the advent of abuse-deterrent formulations.

In this symposium, two nationally recognized pain specialists will examine this dilemma from both a clinical and a pharmacologic perspective. They will discuss how rapid entry into the brain leads to euphoria: a key risk factor in making currently available opioids attractive for abuse. Further, they will describe how the investigational agent, NKTR-181, a new chemical entity characterized by slow entry into the brain, may address the still unmet need of providing effective pain relief without the high levels of euphoria that often cause abuse and addiction.

Learning Objectives
At the conclusion of this program, participants will be able to:

  • Gain a better understanding of the issues patients are facing when seeking treatment for their chronic pain
  • Describe how the pharmacologic properties of currently available opioids have contributed to the opioid epidemic
  • Discuss issues and limitations with currently available opioids, inclusive of abuse-deterrent formulations, and the connection between rapid uptake into the brain and likability
  • Describe unique properties that make NKTR-181 a potential new treatment option for chronic pain management including its molecular design, slow-entry CNS pharmacokinetics, efficacy, safety and low potential for abuse

Jeffrey Gudin, MD
Richard Rauck, MD

Pre-registration not required. Please arrive at least 15 minutes prior to start time.

Contact Name
Suresh Siddhanti

Contact Phone
(415) 482-5772

Contact email


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