Stepwise Interventions for Pain from ADPKD

A systematic literature review published in the May issue of Journal of Urology offers guidance on the management of pain arising from autosomal dominant polycystic kidney disease (ADPKD). The researchers found that for most patients with ADPKD, pain occurs due to renal, hepatic, and mechanical origins. Patients may experience different types of pain complicating confirmation of etiology. A stepwise approach is recommended for management of chronic pain in ADPKD, which according to the authors is often refractory to conservative, noninvasive treatments.

ADPKD is an inherited systemic disorder with major renal manifestations and, in some cases, abnormalities in the liver, the pancreas, the brain, the arterial blood vessels, or a combination of these sites. Acute causes of renal pain occur with high incidence and should be ruled out first. For chronic pain, nonopioid analgesics and conservative interventions can be used before engaging opioid analgesics. Surgical interventions such as renal cyst decortication, renal denervation, and nephrectomy can target pain from persistent renal or hepatic cysts.

Read more about the recommendations, with link to the journal article, here.

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