Results of a new study published in the journal Pain may lead to better understanding of the causes of Complex Regional Pain Syndrome (CRPS) according to researchers at the University of Liverpool. The findings, from experiments with mice, suggest that serum auto-antibodies may contribute to the pathophysiology of CRPS.
In the study, mice were injected with the antibodies from CRPS sufferers, resulting in significantly more swelling of the affected limbs compared to mice injected with antibodies from healthy volunteers. Similar to what is seen in patient’s limbs, the paws of CRPS-antibody injected mice became more painful to pressure, and the paw tissues contained a higher concentration of the nerve-mediator Substance P. The results support the hypothesis that autoantibody-removing therapies may be effective treatments for long-standing CRPS. A news story, with link to the study abstract, may be read here.