Here are some facts about prolotherapy:
It is experimental, painful, not approved by FDA, expensive, and unproven. It is not covered by insurance. People have been asking these prolotherapy advocates - how they determine which tendon or ligament is 'loose' - they have no response. They have no way of measuring if their treatment 'tightens' these supposed 'loose' ligaments/tendons. They do not have any MRI to compare pre and post prolotherapy treatment which demonstrates the ligament or tendon being repaired...This would be very easy to provide if, in fact, it did help. This is why insurance will not cover the cost (normally you will be charged over $2500 for treatment).
—Jeffrey D. Lazar, MD, PhD