Results of a study published in the journal Inflammatory Bowel Diseases suggest that there is “compelling evidence” of alterations of DNA in several regions of the genome in children with Crohn’s disease (CD) that may be related to key environmental exposure. In addition to providing new insights into how genes and the environment interact, the findings may suggest new approaches for clinical management of CD.
The study called out "highly significant" changes in two specific gene locations, including genes responsible for immune and cellular functions that could contribute to the development of CD. Two probes for these locations proved to accurately predict which children would have CD, providing a potentially useful "biomarker" for use as a diagnostic test. A news story about the study findings, with link to the study abstract, may be read here.