New findings published in the August issue of the journal Pain suggest that TRPV4, an ion channel protein that allows calcium to rapidly enter cells, may play a role in inflammation and pain associated with TMJD. Effective treatments are currently lacking for TMJD, the most common form of oral or facial pain, affecting over 10 million Americans. The chronic disorder can cause severe pain often associated with chewing or biting down. The results of the study on mice suggest that TRPV4 and its expression in trigeminal sensory neurons contribute to TMJD pain. Given the lack of effective treatments for this chronic pain disorder, TRPV4 may be an attractive target for developing new therapies. Read more about the research here.