Scientists studying induced nerve injury in rodents have found that the analgesic effects of morphine can decline over time. When morphine is used in combination with carbamazepine, which prevents epileptic seizures, this loss of drug efficacy may be reversed.
There has been mixed efficacy in general using opioids to treat neuropathic pain. The pain relief brought about by morphine can diminish over time. In this study, when carbamazepine was added to the morphine regimen, opioid induced hyperalgesia was reversed. As reported in PLOS ONE, the combination of drugs administered to rodents showed that “the dampening of the analgesic effects of morphine on neuropathic pain behavior in vivo can be countered with the addition of CBZ.”
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