In a study in the journal Pain provides evidence that painful diabetic peripheral neuropathy (DPN) is caused in part by the central nervous system (CNS). Dr. Solomon Tesfaye, Sheffield (UK) Teaching Hospitals NHS Foundation Trust in the United Kingdom states, "Although DPN has been considered a disease of the peripheral nerve, from numerous studies it is becoming apparent that there are indeed changes within the CNS that...appear to be concomitant with the evolution of painful and painless DPN."
Advanced imaging is providing new insights into DPN, which occurs in half of diabetics. Although studies have highlighted the dying back of nerve cells and the loss of nerve cell insulation, new evidence shows that small blood vessel disease leads to hypoxia of the peripheral nerves and contributes to DPN. Further studies are needed.
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Access the journal abstract, here.