Diagnosis and Management of Centralized Pain

The most significant clinical understanding of recent times is that a peripheral nerve injury that causes pain may cause imprinting of pain’s memory in the central nervous system (CNS). This occurs when inflammatory mediators from the peripheral pain site enter the CNS and activate glial cells to produce inflammation. Practitioners are taught how to diagnose, treat, and prevent this condition. CNS inflammation is a progressive, tissue destructive process that requires treatment strategies that are relatively new to pain treatment.

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